Antibiotic and antifungal characteristics of moringa (Moringa oleifera)

Authors

  • Tushar Sharma Department of Biotechnology & Bioinformatics, North-Eastern Hill University, Shillong-793022 (Meghalaya), India

Keywords:

antibacterial, antifungal, antimicrobial, moringa, wound healing

Abstract

To summarize the antibacterial, antifungal, and wound-healing properties of moringa (Moringa oleifera), a review of the literature has been conducted. It has been shown that Moringa oleifera is a rich source of antioxidants, phenolic compounds, and a variety of other biochemicals e.g. tannins, saponins, flavonoids, and steroids. In the plant, these organic substances have potent antimicrobial, antibacterial, and antifungal properties. The features of Moringa oleifera, present in its leaves, flowers, pod, bark, and roots, developed wound-healing properties in a variety of forms, including fresh, powdered, and extracts.

References

Abdullah A, Al-Ghanayem, Alhussaini M S, Asad M and Joseph B. 2022. Effect of Moringa oleifera leaf extract on excision wound infections in rats: antioxidant, antimicrobial, and gene expression analysis. Molecules. 27(14): 4481.

Ahmadua T, Ahmad K, Ismail S I, Rashed O and Asib N. 2020. Omar D. Antifungal efficacy of Moringa oliefera leaves and seed extract against Botrytis cinerea causing graymold disease of tomato. Braz. J. Biol. 81:1007–1022.

Ahmed M, Marrez D A, Abdelmoeen N M, Mahmoud E A, Ali M A S, Decsi K and Tóth Z. 2023. Proximate analysis of Moringa oleifera leaves and the antimicrobial activities of successive leaf ethanolic and aqueous extracts compared with green chemically synthesized Ag-NPs and crude aqueous extract against some pathogens. Int. J. Mol. Sci. 24(4): 3529.

Ali G H, El-Taweel G E and Ali M A. 2004. The cytotoxicity and antimicrobial efficiency of Moringa oleifera seeds extracts. Int. J. Environ. Stud. 61:699-708.

Al-Khalasi S, Al-Ghafri A, Al-Saqri S, Al-Jahdhami H, Al-Hosni S and Elmiligy Y. 2024. Antifungal activity of Moringa peregrina plant extracts against Candida kruzei. European Journal of Theoretical and Applied Sciences. 2(2): 87-101.

Amagloh F K and Benang A. 2009. Effectiveness of Moringa oleifera seed as coagulant for water purification. Afr J Agric Res. 4:119-123.

Amer J, Raheela J, Muhammad S and Muhammad A. 2008. Microscopic evaluation of the antimicrobial activity of seeds extracts of Moringa oleifera. Pak J Bot. 40(4):1349-1358.

Anzano A, De Falco B, Ammar M, Ricciardelli A, Grauso L, Sabbah M, Capparelli R and Lanzotti V. 2022. Chemical analysis and antimicrobial activity of Moringa oleifera Lam. leaves and seeds. Molecules. 27: 8920.

Aondo T O, Odiaka N I, Akesa T M, and Olaleye O O. 2018. Phytochemical and antifungal efficacy of different parts of Moringa oleifera plant extracts. Asian Journal of Biotechnology and Bioresource Technology. 3(2): 1-8.

Arama P F, Wagai S O, Ogur J A, Walter A O, Owido S O and Mahagayu C M. 2011.Harvesting surface rainwater – purification using Moringa oleifera seed extracts and aluminum sulfate. Journal of Agricultural Extension and Rural Development. 3(6): 102-112.

Ashames A, Ijaz M, Buabeid M, Yasin H, Yaseen S, Bhandare R R and Murtaza G. 2024. In Vivo wound healing potential and molecular pathways of amniotic fluid and Moringa Olifera-loaded nanoclay films. Molecules. 29(3): 729.

Awodele O, Oreagba I A, Odoma S, Jaime A, Da Silva T and Osunkalu V.O. 2012. Toxicological evaluation of the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae) J. Ethnopharmacol. 139: 330–336.

Ayyanar M, Krupa J, Jenipher C, Amalraj S and Gurav S S. 2023. Phytochemical composition, in vitro antioxidant and antibacterial activity of Moringa concanensis nimmo leaves. Vegetos Retrieved from https://link.springer.com/article/10.1007/s42535-023-00663-9.

Berkowitz F E. 1995. Antibiotic resistance in bacteria. South Med. Journal. 88: 797-804.

Bhatt K K S. 1995. Medicinal Plant Information Databases. FAO-Food and Organization of the United Nations Italy. 11: 163.

Bhattacharya A, Tiwari P, Sahu P K, Kumar S A. 2018. Review of the phytochemical and pharmacological characteristics of Moringa oleifera. J. Pharm. Bioallied Sci. 10: 181–191.

Bhattacharya S B, Das A K and Banerji N. 1982. Chemical investigations on the gum exudate from sajna (Moringa oleifera). Carbohydr. Res. 102: 253-262.

Bichi M H and Shehu U H. 2018. Antimicrobial properties of Moringa oleifera seed oil. International Journal of Research in Earth & Environmental Sciences. 13(1).

Bijal A and Bhumika D. 2015. Antibacterial activity and phytochemical screening of different parts of Moringa oleifera against selected gram positive and gram negative bacteria. Journal of Pharmaceutical, Chemical and Biological Sciences. 3(3): 421-425.

Biswas S K, Chowdhury A, Das J, Roy A and Hosen S M Z. 2012. Pharmacological potentials of Moringa oleifera lam.: a review. International Journal of Pharmaceutical Sciences and Research. 3(2): 305-310.

Bukar, A, Uba, A. and Oyeyi, T I. 2010. Antimicrobial profile of Moringa oleifera Lam. extracts against some food – borne microorganisms. Bayero Journal of Pure and Applied Sciences, 3(1): 43 – 48.

Caceres A, Cabrera O, Morales O, Mollinedo P, Mendia P. 1991. Pharmacologic properties of Moringa oleifera: preliminary screening for antibacterial activity. Journal of Ethnopharmacology. 33: 213-216.

Caceres A, Saravia A, Zabala L, Leon E. 1992. Pharmacologic properties of Moringa oleifera. 2: screening for antispasmodic, anti-inflammatory and diuretic activity. J Ethnopharmacol. 36: 233-237.

Chen H M, Chuang P H, Lee C W, Chou J Y, Murugan M, Shieh B J. 2007. Anti-fungal activity of crude extracts and essential oil of Moringa oleifera Lam. Bioresour Technol. 98: 232–236.

Chopra R N, Nayar S L, Chopra I C. 1956. Glossary of Indian Medicinal Plants. 1st Edition, CSIR, New Delhi. 2: 66-6.

Chuang P H, Lee C W, Chou C Y, Murugan M, Shieh B J and Chen H M. 2007. Anti-fungal activity of crude extracts and essential oil of Moringa oleifera Lam. Bioresour. Technol. 98: 232-236.

Dahot M U. 1998. Vitamin contents of flower and seeds of Moringa oleifera Lam. J Islamic Academy Sci. 11(1): 27-32.

Dhimmar N D, Patel N M, Gajera V and Lambole V. 2015. Pharmacological activities of Moringa oleifera: an overview. Research Journal of Pharmacy and Technology. 8(4): 476-480.

Dinesha B L, Nidoni U, Ramachandra. C T, Naik N, Sankalpa K B. 2018. Effect of extraction methods on physicochemical, nutritional, antinutritional, antioxidant and antimicrobial activity of moringa (Moringa oleifera Lam.) seed kernel oil. J. Appl. Nat. Sci. 10: 287–295.

Doughari J H, Pukuma M S and De N. 2007. Antibacterial effects of Balanites aegyptiaca L. Drel. and Moringa oleifera Lam. on Salmonella typhi. Afr J Biotechnol. 6(19): 2212-2215.

Dzotam J K, Touani F K, and Kuete V. 2016. Antibacterial and antibiotic-modifying activities of three food plants (Xanthosoma mafaffa Lam, Moringa oleifera (L.) Schott and Passiflora edulis Sims) against multidrug-resistant (MDR) Gram-negative bacteria. BMC complementary and alternative medicine. 16(1).

Eilert U, Wolters B, Nahrstedt A. 1981. The antibiotic principle of seeds of Moringa oleifera and Moringa stenopetala. Planta Med. 42: 55-61.

Fahey J W, Zalcmann A T, Talalay P. 2001. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry, 56(1): 5-51.

Fahey J W. 2005. Moringa oleifera: a review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees Life J. 1: 5.

Farnsworth N R. 1991. Biological and phytochemical screening of plants. J. Pharmacol. Sci. 55: 225-276.

Ghebremichael K A, Gunaratna K R, Henriksson H, Brumer H. and Dalhammar G. 2005. A simple purification and activity assay of the coagulant protein from Moringa oleifera seed. Water Re.s 39: 2338–2344.

Han S S, Keum Y S, Seo H J and Surh Y J. 2002. Curcumin suppresses activation of NF-B and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. J. Biochem. Mol. Biol. 35: 337- 342.

Isitua C C, Ibeh I and Olayinka J N. 2016. In Vitro antifungal activity of Moringa oleifera Lam leaf on some selected clinical fungal strains. Indian Journal of Applied Research. 6(8).

Jabeen R, Shahid M, Jamil A and Ashraf M. 2008. Microscopic evaluation of the antimicrobial activity of seed extracts of Moringa oleifera. Pak. J. Bot. 40:1349.

Jamil A, Raheela J, Muhammad S and Muhammad A. 2008. Microscopic evaluation of the antimicrobial activity of seed extracts of Moringa oleifera. Pak J Bot. 40(4):1349-1358.

Kekuda T R P, Mallikarjun N, Swathi D, Nayana K V, Aiyar M B and Rohini T R. 2010, Antibacterial and Antifungal efficacy of steam distillate of Moringa oleifera Lam. J Pharm Sci and Res. 2(1): 34-37.

Khanitta R and Angelika P. 2015. Antimicrobial activities of Moringa oleifera seed and seed oil residue and oxidative stability of its cold pressed oil compared with extra virgin olive oil. Songklanakarin Journal of Science and Technology. 37(5): 587-594.

Kishore A and Goitom K. 2021a. Nutritional evaluation of Moringa oleifera pod meal for white New Zealand rabbits. The Journal of Rural Advancement. 9(2): 43–50. Retrieved from http://jra.idtra.co.in/index.php/jra/article/view/29

Kishore A and Goitom K. 2021b. Thermal effect on general and excretion behaviour of White New Zealand rabbit kept on moringa (Moringa oleifera) pod meal. The Journal of Rural Advancement. 9(1): 1–6. Retrieved from http://jra.idtra.co.in/index.php/jra/article/view/23.

Kishore A and Goitom K. 2022. Ethogram of rabbits on concentrate feed with and without moringa pods. Indian Journal of Small Ruminants. 28(2): 315-319.

Kone W M, Atindeou K K, Terreaux C, Hostettmann K, Traore D and Dosso M. 2004. Screening of 50 medicinal plants for antibacterial activity. Journal of Ethnopharmacol. 93: 43-49

Lar P M, Lojile E E, Dashe E and Oluoma J N. 2011. Antibacterial activity of Moringa oleifera seed extracts on some gram negative bacterial isolates. African Journal of Natural Sciences. 14: 57 – 62.

Maurya S K and Singh A K. 2014. Clinical Efficacy of Moringa oleifera Lam. Stems Bark in Urinary Tract Infections. Int. Sch. Res. Not. 906843.

Mbikay M. 2012. Therapeutic potential of Moringa oleifera leaves in chronichyperglycemia and dyslipidemia: A review. Front Pharmacol. 3: 1-12.

Mehta L K, Balaraman R, Amin A H, Bafna P A and Gulati O D. 2003. Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits. J Ethnopharmacol. 86: 191–195.

Mishra G, Singh P, Verma R, Kumar S, Srivastav S, Jha K K and Khosa R L. 2011. Traditional uses, phytochemistry and pharmacological properties of Moringa oleifera plant: An overview. Der Pharmacia Lett. 3: 141–164.

Moodley J S, Krishna S B N and Pillay K. 2018. Green synthesis of silver nanoparticles from Moringa oleifera leaf extracts and its antimicrobial potential. Adv. Nat. Sci. Nanosci. Nanotechnol. 9: 1–10.

Muhammad A A, Arulselvan P, Cheah P S, Abas F and Fakurazi S. 2016. Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. Drug Des. Devel. Ther. 10:1715–1730.

Nadkarni K M and Nadkarni A K. 1976. The Indian Materia Medica with Ayurvedic, Unani-Tibbi, Siddha, Allopathic, Homeopathic, Naturopathic and Home remedies. Popular Prakashan Pvt. Ltd, Bombay, pp. 810.

Nantachit K. 2006. Antibacterial activity of the capsules of Moringa oleifera Lamk. Moringaceae. CMU J. 5(3): 365-368.

Nepolean P, Anitha J and Emilin R R. 2009. Isolation, analysis and identification of phytochemicals of antimicrobial activity of Moringa oleifera Lam. Curr. Biotica. 3: 33-39.

Nikkon F, Saud A, Rahman M H and Haque M E. 2003. In vitro antimicrobial activity of the compound isolated from chloroform extract of Moringa oleifera Lam. Pak J Biol Sci. 6(22): 1888–1890.

Novitarini, Jason Merari P and Marlina D. 2022. Antibacterial Activity of Moringa Plants (Moringa oleifera Lam.) to Overcome Antibiotic Resistance: A Systematic Review. Bioscientia Medicina. 6(10): 2259-2273.

Nwosu M O and Okafor J I. 1995. Preliminary studies on the antifungal activities of some medicinal plants against basidiobolus and some other pathogenic fungi. Mycoses. 38(5-6): 191-195.

Oloduro A O and Aderiye B I. 2007. Efficacy of Moringa oleifera seed extract on the microflora of surface and underground water. J. Plant Sci. 2: 453-458.

Padla E P, Solis L T, Levida R M, Shen C C, Ragasa C Y. 2012. Antimicrobial isothiocyanates from the seeds of Moringa oleifera Lam. Z. Für Nat. C. 67: 557–564.

Patel N and Mohan J S S. 2018. Antimicrobial activity and phytochemical analysis of Moringa oleifera Lam. crude extracts against selected bacterial and fungal strains. Int. J. Pharmacogn. Phytochem. Res. 10, 68–79.

Peixoto J R, Silva G C, Costa R A. 2011. In vitro antibacterial effect of aqueous and ethanolic moringa leaf extracts. Asian Pac. J Trop Med. 4: 201-204.

Pinal P, Nivedita P, Dhara P, Sharav D, and Dhananjay, M. 2014. Phytochemical analysis and antifungal activity of Moringa oleifera. International Journal of Pharmacy and Pharmaceutical Sciences. 6(5).

Prashith K T R, Mallikarjun N, Swathi D, Nayana K V, Aiyar M B, Rohini T R. 2010. Antibacterial and antifungal efficacy of steam distillate of Moringa oleifera Lam. Pharm Sci Res. 2(1): 34-37.

Rahman M M, Sheikh M M I, Sharmin S A, Islam M S, Rahman M A, Rahman M M, Alam M. 2009. Antibacterial activity of leaf juice and extracts of Moringa oleifera Lam against some human pathogenic bacteria. CMU J Nat Sci. 8(2):219.

Rao R R, George M and Pandalai K M. 1946. Pterygospermin: the Antibacterial Principle of Moringa pterygosperma, Gaertn. Nature. 158: 745-746.

Rastogi T, Bhutda V, Moon K, Aswar K B and Khadabadi S S. 2009. Comparative studies on anthelmintic activity of Moringa oleifera and Vitex negundo. Asian J. Res. Chem. 2:181-182.

Ravindra A V, Rao P S and Siddheshwar S S. 2019. A pharmacological review on Moringa oleifera. World Journal of Pharmaceutical Research. 8(8): 910-920.

Renitta R E, Nepolean P and Anitha J. 2009. Isolation, analysis and identification of phytochemicals of antimicrobial activity of Moringa oleifera Lam. Current Biotica. 3(1):33-39.

Saadabi A M and Abu Z A I. 2011. An in vitro antimicrobial activity of Moringa oleifera L. seed extracts against different groups of microorganisms. Asian J. Basic Appl. Sci. 5:129-134.

Schwarz D. 2000. Water clarification using Moringa oleifera. Technical Information W1e, Gate Information Service, Eschborn, Germany.

Shafie N M, Shah R N I R S, Krishnan P, Haleem N A and Tan T Y C. 2022. Scoping Review: Evaluation of Moringa oleifera (Lam.) for potential wound healing in in vivo studies. Molecules. 27(17): 5541.

Sharma T, Kishore A and Singh P. 2022a. Phenolic, antioxidant and free radical-scavenging properties of various parts of Indian moringa (Moringa oleifera) during the winter season. The Journal of Rural Advancement, 10(01): 1–7. Retrieved from https://jra.idtra.co.in/index.php/jra/article/view/30.

Sharma T, Kumar A and Kishore A. 2022b. Seasonal variation in antioxidant properties of various parts of the Moringa oleifera plant collected from different Indian locations. The Journal of Rural Advancement. 10(01): 13–18. Retrieved from https://jra.idtra.co.in/index.php/jra/article/view/32.

Shekhar C, Shukla R, Kumar Aand Dubey N K. 2000. Laboratory of Herbal Pesticides, Centre of advance study on botany, Banaras Hindu University, Varanasi, India. Eur J Clin Microbiol Infectious Dis. 6:23-28.

Suarez M, Entenza J M, Doerries C, Meyer E, Bourquin L, Sutherland J, Marison I, Moreillon, P. et al. 2003. Expression of a plant-derived peptide harboring watercleaning and antimicrobial activities. Biotechnol Bioeng. 81: 13–20.

Upadhyay P, Yadav M K, Mishra S, Sharma P, Purohit S. 2015. Moringa oleifera: A review of the medical evidence for its nutritional and pharmacological properties. Int. J. Res. Pharm. Sci. 5:12–16.

Verpoorte R. 2000. Pharmacognosy in the new millennium: lead finding and biotechnology. J. Pharm. Pharmacol, 52: 253- 262.

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Published

2024-04-01

How to Cite

Sharma, T. (2024). Antibiotic and antifungal characteristics of moringa (Moringa oleifera). The Journal of Rural Advancement, 12(1), 34–49. Retrieved from http://jra.idtra.co.in/index.php/jra/article/view/6