Pharmacological and formulation studies on growth hormone: in-vivo and in-vitro
Keywords:
Growth hormone, Niosomes, Noisome, Pharmacokinetic data, SomatotropinAbstract
Human growth hormone (HGH), also known as somatotropin, Growth hormone is indicated in many diseases, like Prader-Willi syndrome, chronic renal insufficiency, Tuner syndrome, AIDS-related wasting, idiopathic short stature in children, and the accumulation of fat in adults with lipodystrophy. A number of carriers have been utilized to carry drugs to target tissues, which include immunoglobulins, serum proteins, synthetic polymers, lipid vesicles, microspheres, niosomes, etc. In this study, in-vivo somatotropin was estimated by ultraviolet spectroscopy, and blood plasma showed an absorption maximum at 214 nm. In-vitro preparation of niosomes by hand shaking method, reverse phase evaporation method, and ether injection method. The niosomal formulation of somatotropin has proven to be highly effective in inducing growth as compared to the existing marketed formulations of somatotropin. As a result, growth hormone can now be synthesized by Escherichia coli bacteria as a result of the successful application of recombinant DNA technology. Therefore, this hormone is now beginning to become available in sufficient quantities for treatment purposes. The niosomal formulation of somatotropin has proven to be highly effective in inducing growth as compared to the existing marketed formulations of somatotropin.
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